(as of Oct 23,2021 11:46:48 UTC – Details)
A Probiotic that Supports Healthy Liver Function*
Paradigm-changing probiotic produces the primary liver health antioxidant, glutathione.*
Glutathione is one of the most important antioxidants in the body. Antioxidants may help protect your cells from the damage done by free radicals. An increasing number of studies link glutathione depletion with an increase in oxidative stress and a greater incidence of disease and accelerated aging. For example, reduced plasma glutathione levels have been shown to represent an increased risk for cardiovascular disease. Glutathione depletion has also been shown to be a primary cause of the neurodegeneration that leads to Parkinson’s disease. Similarly, increased oxidative stress in Alzheimer’s disease has been attributed to decreased levels of glutathione in the brain.
After discovering that Lactobacillus fermentum ME-3 expresses strong antioxidant activity, follow-up studies began to reveal that ME-3 produces a wide range of additional health benefits. ME-3’s multiple benefits fall within four categories: antioxidant activity, immune system support, anti-inflammatory activity, and detoxification. Consequently, scientists have been studying ME-3 for the past 20 years, and its unique health-promoting benefits are summarized below.
* Promotes Cardiovascular Health: Lactobacillus fermentum ME-3 has a beneficial effect on several cardiovascular risk factors.
* Enhances Detoxification: Glutathione is a critical regulator of detoxification in every cell of the body, but especially in the liver and kidneys. Glutathione detoxifies toxins in food, heavy metals, air pollutants, pharmaceuticals, and a wide range of other toxins.
* Promotes Liver Health: The liver is the primary organ for detoxification. There are two main phases of detoxification in the liver, which are called Phase 1 and Phase 2 detoxification pathways. A significant number of free radicals are generated during Phase 1, which can result in liver damage if adequate antioxidants (especially glutathione) are not available to quench them.
* Reduces Inflammation: Lactobacillus fermentum ME-3 has been shown to significantly inhibit levels of several key inflammatory markers, including glycated hemoglobin (HbA1c), high sensitivity C-reactive protein (hs-CRP), and interleukin 6 (IL-6).
* Promotes Healthy Bacterial Balance: ME-3 produces significant amounts of short-chain fatty acids (SCFAs), hydrogen peroxide, and nitric oxide.37 These postbiotic metabolites function in several ways to promote the growth of beneficial bacteria and suppress the growth of pathogens, which help maintain a healthy microbiome.
* Detoxifies Organophosphate Pesticides: Organophosphates were developed in the 1940s as highly toxic biological warfare agents. Today, they are one of the most widely used pesticides worldwide. In addition to being sprayed on agricultural food crops, they occur in many pesticide and insecticide products commonly used on residential lawns and gardens
* Immune Function: Lymphocytes are a critical component of the immune system. Their primary job is to defend us against bacteria, viruses, and other foreign invaders. When faced with a challenge, the body dramatically increases the production of lymphocytes to fight the infection. Glutathione is required for the production and function of lymphocytes.
Reg´Activ Detox & Liver Health contains the revolutionary probiotic strain Lactobacillus fermentum ME-3. Studied for over 20 years, ME-3 produces glutathione and ME-3 has been found to support healthy glutathione levels in the cardiovascular system.*
Glutathione is the body’s “Master Antioxidant.” It is used by every cell in the human body, and it’s absolutely vital for heart health. In the cardiovascular system, glutathione affects how the body processes LDL cholesterol in a healthy fashion. Glutathione’s effects ultimately support the health of the endothelium (vascular lining).*
The probiotic strain, Lactobacillus fermentum ME-3, has been proven to support healthy glutathione levels. It achieves this effect through three unique pathways:
ME-3 synthesizes glutathione itself* ME-3 extracts available glutathione molecules from its surrounding environment* ME-3 recycles “spent” (reduced) glutathione (GSSG) back into its active state (GSH)*
Each daily dose (2 capsules) contains 6 billion viable bacteria. This is like ingesting 6 billion little glutathione manufacturing factories every day, which results in a constant production of glutathione. In human clinical trials, people taking ME-3 gained a 49% increase in the ratio between reduced to oxidized glutathione, which equates to a significant increase in levels of active glutathione in the body.
Reg´Activ DETOX & LIVER HEALTH pairs this powerhouse probiotic strain with additional, more familiar liver health nutrients. Many herbal and nutritive approaches to supporting liver health work well on the glutathione system. Consequently, they all complement ME-3’s activities:
L-selenothionine (easy-to-digest selenium) – Promotes healthy levels of the enzyme glutathione peroxidase, which supports liver tissue health*
L-methionine & N-Acetyl-cysteine – Act as glutathione precursors*
Milk thistle extract (Silymarin) – Supports production of super antioxidant enzymes in the liver*
What Exactly is Glutathione?
Glutathione is a tripeptide compound synthesized from the amino acids glutamine, glycine and cysteine. It is considered the “Master Antioxidant” because it is made and used in every cell in the body. Glutathione also helps regenerate other dietary antioxidants such as vitamins C and E.*
This powerful antioxidant is essential for cells and tissues that experience high amounts of wear and tear on a daily basis, such as liver cells, cardiovascular tissues, and immune system cells.
Why You Need to Take a Glutathione Supplement:
All human cells can produce glutathione, but its production can be challenged by cysteine availability in the diet. Glutathione levels also naturally decline with age. So supplementation seems attractive. Unfortunately, as a compound, glutathione is hard to supplement successfully.
Glutathione appears to degrade in the gut when taken orally, since it is a protein. Reg´Activ products address this challenge by providing a living probiotic strain that produces glutathione from within the body.
HOW GLUTATHIONE REGULATES ALCOHOL DETOXIFICATION
Everyone knows that consuming high levels of alcohol is toxic. So how does alcohol cause toxicity and what can be done to protect yourself against damage due to over indulgence of alcohol?
ALCOHOL METABOLISM: The metabolism of alcohol is a two-step process that takes place in the liver. In the first step, an enzyme named alcohol dehydrogenase converts alcohol into compound named acetaldehyde, which is called an intermediate metabolite.
In the second step, an enzyme named glutathione-S transferase facilitates the joining of acetaldehyde with glutathione and the acetaldehyde-glutathione complex is easily excreted in the urine. When adequate levels of glutathione are available in the liver, alcohol detoxification goes smoothly. However, one evening of heavy drinking will quickly deplete the liver’s stores of glutathione.
The body’s available glutathione levels are always being depleted during alcohol detoxification. Thus, people who regularly consume alcohol at moderate levels, such as one or two drinks a day, are also constantly lowering their level of available glutathione.
ACETALDEHYDE TOXICITY: It is important to realize that acetaldehyde is estimated to be from 20 to 30 times more toxic than alcohol. Acetaldehyde destroys enzymes and proteins it comes into contact with and it also causes DNA damage. Elevated levels of acetaldehyde in the liver destroys liver cells and leads to alcoholic liver disease (ALD). And finally, acetaldehyde is highly neurotoxic. Hence, elevated levels of acetaldehyde damage nerves and accelerate cognitive decline.
The damage from excess drinking is not due to the alcohol, but rather, to the toxic effects from acetaldehyde. When glutathione levels in the body are not adequate to keep up with the amount of acetaldehyde being produced during the first phase of alcohol detoxification, acetaldehyde begins to exert its powerful damaging effects.
GLUTATHIONE DEPLETION: The second factor has to do with the wide-ranging effects of glutathione. Glutathione is referred to as the Master Antioxidant and it is also a key regulator of the immune system and of detoxification in all cells throughout the body. When glutathione levels are depleted due to alcohol consumption, the whole body suffers. Free radical damage increases, the immune system is weakened and toxins begin to build up in the body.
BOOST GLUTATHIONE LEVELS WITH REG’ACTIV: Reg’Activ Detox & Liver Health from Essential Formulas is a very effective method of boosting glutathione levels. It contains Lactobacillus fermentum ME-3 (or just ME-3), which is a strain of probiotic bacteria that synthesizes glutathione. Each daily dose (2 capsules) contains 6 billion viable bacteria. This is like ingesting 6 billion little glutathione manufacturing factories every day, which results in a constant production of glutathione. In human clinical trials, people taking ME-3 gained a 49% increase in the ratio between reduced to oxidized glutathione, which equates to a significant increase in levels of active glutathione in the body.
Increase the level of the master antioxidant. Glutathione is the body’s “Master Antioxidant.” It is used by every cell in the human body, and it’s absolutely vital for hepatic function. Compared to all other organs, glutathione is found at its highest concentrations in the liver. ME-3 provides both glutathione and glutathione precursors.
Improve your liver health. ME-3 is paired with additional, more familiar liver health nutrients, all complementing ME-3’s activities. L-selenothionine (easy-to-digest selenium) – Promotes healthy levels of the enzyme glutathione peroxidase, which supports liver tissue health* L-methionine & N-Acetyl-cysteine – Act as glutathione precursors* Milk thistle extract (Silymarin)
Helps with alcohol detoxification. Supports the production of super antioxidant enzymes in the liver. See below for more on how glutathione regulates alcohol detoxification.
Best of Supplements award winner 2017. Gluten free, vegetarian.